Talk:Bismuth subsalicylate

Pepto-Bismol

Also, how about a structure? And an X-ray crystal structure?

I'm wrapping the brand name Pepto-Bismol in [['s, to make it appear on the requested articles page. I think that this particular (exclusive maybe? I don't know) brand use of bismuth subsalicylate deserves a wikipage, due to its reference in both popular media, and it being almost a monopoly in the stomach-calming-medicines market. Additionally, if anyone could provide more information about the method of action of Bismuth Subsalicylate I would be much obliged. --Lor 04:00, 1 Apr 2005 (UTC)

Aha, well bismuth subsalicylate redirects here. I shall undo the change in that case - but I would like to suggest for the reasons above that Pepto-Bismol be given its own seperate article? Sorry again, --Lor 04:05, 1 Apr 2005 (UTC)

And after only two years, I decided to give it it's own article. The wheels of Wikipedia grind slowly, but let's see Encarta cover this. --ByeByeBaby 07:42, 16 April 2007 (UTC)

I think that this article needs to be entirely re-written in light of this new reference: "Bismuth-containing antacids (unless chelates) are not recommended because absorbed bismuth can be neurotoxic, causing encephalopathy" British National Formulary (BNF), Sept 2016-Mar 2017, p. 61. I leave any changes to wiser heads----[User:Baffle]

Gallery of Advertisements featuring Pepto-Bismol

I'd like to add the following link within the main article.

http://advertising.tjs-labs.com/gallery-view?product=PEPTO+BISMOL&op=AND&span=1000&sort=B

Please advise soonest.--15.235.153.104 20:02, 26 October 2006 (UTC)

The link does not comply with wp:el, and it does not give any extra information about the chemical, I don't think this is a good place for the link. --Dirk Beetstra ^{T C} 20:04, 26 October 2006 (UTC)

I agree that the link has nothing to do with the chemical. However, it has everything to do with Pepto-Bismol (which is how I found this page, btw). There are links to the "official" Pepto and Kaopectate sites here. Perhaps there should be a separate Pepto-Bismol article. --15.235.153.104 20:08, 26 October 2006 (UTC)

You are right, I removed those as well. Your link would still not comply with wp:el. --Dirk Beetstra ^{T C} 20:11, 26 October 2006 (UTC)

Action, perhaps a link

This page is more linked to organic rather than inorganic chemistry, the action is the same as salicylic acid(asprin). It is just the bismuth salt, like sodium acetate is that salt of acetic acid. A link to asprin would be useful. —The preceding unsigned comment was added by Spgoo1 (talk • contribs) 08:51, 18 March 2007 (UTC).

Uhhh... except that aspirin is acetylsalicylic acid, and it tends to irritate the stomach rather than calm it.Zaphraud (talk) 02:38, 16 March 2009 (UTC)

Action, perhaps a link

This page is more linked to organic rather than inorganic chemistry, the action is the same as salicylic acid(asprin). It is just the bismuth salt, like sodium acetate is that salt of acetic acid. A link to asprin would be useful. Spgoo1 08:53, 18 March 2007 (UTC)

I notice that the article text says this compound is a salt, as does the above contributor. But the structure shown does not look like a salt. It looks like the bismuth is covalently bound. Does it dissociate into ions when dissolved in water? If not, it's not a salt. If so, the structure may need correcting. E.g., with the organic salt sodium acetate, we do not draw a covalent bond between the sodium and the acetate. 152.5.254.24 (talk) 17:15, 4 December 2008 (UTC)

I think the term "salt" doesn't quite apply to this compound, so I have reworded the statement. -- Ed (Edgar181) 01:38, 5 December 2008 (UTC)

"salt" just means any compound that is formed as a biproduct of an acid/base reaction. salts do not have to dissolve in water; in fact, many don't. in regards to the structure, it is perfectly acceptable to draw a bond between the cation and anion to indicate which atoms primarily interact, distribution in space, etc. bismuth subsalicylate IS a salt and we DO draw a bond between the bismuth and carboxylate side chain. it is up to the reader to recognize that a drawn bond does not necessarily mean the bond is 100% ionic or 100% covalent, but that it could be either or a mixture (as in HCl) and must be determined by basic chemical knowledge. — Preceding unsigned comment added by Burningbend (talk • contribs) 03:37, 13 February 2012 (UTC)

Radioactive?

Hi. The article on Bismuth states that bismuth is radioactive. If that's true, wouldn't pepto-bismol causeside effects due to its radioactivity? Or, would bismuth have to stay in the body for along time to release any radioactive particles? Should this be mentioned in the article? Thanks. – AstroHurricane001^{(Talk+Contribs+Ubx)(+sign here+How's my editing?)} 14:40, 14 April 2007 (UTC)

Bismuth has 98 radioactive isotopes. None of them occur naturally. Naturally occuring bismuth is stable.--Mycroft.Holmes 15:02, 14 April 2007 (UTC)

Actually it isn't stable, but its half-life is comparable to the age of the universe, so it's safe --Cubbi 21:39, 7 June 2007 (UTC)

Added information from Pepto Bismol FAQ page

http://www.pepto-bismol.com/faqs.shtml Instead of just mentioning the black tongue thing and scaring people away from something, I think explaining why it happens, and adding a sentence on how it is perfectly harmless, is also important. So thats what I did. My information comes from the official Pepto-bismol homepage FAQ, since I went there to see what all this black tongue stuff was about. Where someone added a "citation needed" thing to where someone mentioned you shouldn't take it when you have chicken pocks or the flu, I'd like to mention that the Pepto Bismol FAQ answers that question as well, it just a standard FDA-mandated warning for aspirin- and non-aspirin-containing products. That sentence doesn't make sense to me though, since everything is either containing or not containing aspirins, so wouldn't it be in everything? Anyway, someone might want to check out that source of information. Dream Focus 06:14, 12 May 2007 (UTC)

Is that an EXTERNAL link?

In the section "External links" there is a link to another wikipedia page that then contains external links. But that particular link is to another wikipedia page, and therefor isn't really an "external" link, but an internal one. Dream Focus 06:17, 12 May 2007 (UTC)

WikiProject class rating

This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 07:52, 10 November 2007 (UTC)

I add a more appropriate IUPAC Name --ChemSpiderMan (talk) 03:22, 16 December 2007 (UTC)

This link refers to branded product

Moving this to Talk, as this article is about the "generic" substance rather than a branded product. (Pepto-Bismol does link to this site.)

• Pepto-bismol official website FAQ

-- Writtenonsand (talk) 20:09, 31 May 2008 (UTC)

Decomposition

Is this section really necessary? Sounds like useless trivia to me. Applying a blowtorch to medications is hardly common practice.Mylon (talk) 18:14, 20 February 2011 (UTC)

I agree with this. I thought the exact same thing when I read this section of the article. This part does not need to be in the main article. --98.70.134.98 (talk) 22:01, 26 April 2011 (UTC)

Why the heterocyclic structure image?

This a typical insoluble and dare I say it, inorganic bismuth "sub-salt" i.e one with extra oxide - they used to call them bismuthyl compounds. As discussed in the article the structure is, as expected, complex- so why the misleading structural image and the IUPAC name? And should it be termed a heterocycle? Axiosaurus (talk) 12:43, 22 December 2013 (UTC)

This paper [[1]]is more recent than the "model" structure paper quoted in the article and it has a structure of the subsalicylate solid state without extraneous organo ligands being present as in the "model". Note that the mechano-synthesis produced a number of compounds, a feature of Bi sub salts is the number of very similar stoichiometries that can be obtained, so the proprietary drug could well be a mixture of different compounds.Axiosaurus (talk) 08:23, 23 December 2013 (UTC)

Unsourced

Moved here per WP:PRESERVE. Per WP:BURDEN, do not restore without finding a reliable source, checking this against it, and citing the source.

Structure

Characterization of the properties of bismuth subsalicylate has been difficult due to its insolubility and its partial hydrolysis. Two crystal structures are observed, they are:

• [Bi₃₈O₄₄(HSal)₂₆(Me₂CO)₁₆(H₂O)₂] with a Bi₃₈O₄₄ core
• [Bi₉O₇(HSal)₁₃(Me₂CO)₅] with a Bi₉O₇ core

It is believed that the latter cluster gives rise to the former, leading researchers to believe that they may be extrapolated to form larger clusters. This may be the basis for bismuth subsalicylate's extreme insolubility.

The term "sub" in the chemical name refers to the high oxygen content in the molecule and the presence of Bi-O moieties. Other bismuth carboxylates have typically been trapped using chelating amines such as bipyridine. Attempts to do so with bismuth subsalicylate have typically led to a loss of the "sub" portion of the molecule.

-- Jytdog (talk) 18:20, 23 March 2017 (UTC)

BRAIN DAMAGE

I have made an edit stating that bismuth-containing anatacids like Pepto Bismol are NEUROTOXIC, and that they cause ENCEPHALOPATHY (BRAIN DAMAGE). This is NOT "based on just one study" as stated by the person who removed my edit. I quoted directly from the British National Formulary (BNF), which is a joint publication of the British Medical Association and the Royal Pharmaceutical Society. There is no more authoritative published textbook in the world for information on drugs.

There is also an overriding public interest in publicizing information that will prevent people from being harmed by dangerous medications. I suggest that the person who removed my edit actually reads the reference that I quote. Baffle (talk) 21:34, 1 May 2018 (UTC)

I've added the BNF's position on bismuth-containing antacids with an accessible source. OhNoitsJamie ^Talk 21:37, 1 May 2018 (UTC)

Thank you for reading the source. I see that you have deleted two very important words when you quote the source: "causes encephalopathy." Could you explain why you redacted those particular words? I see that you left in "neurotoxicity" and "constipation." Could it be because encephalopathy is a fancy word for brain damage?Baffle (talk) 21:48, 1 May 2018 (UTC)

I have replaced the two words removed from the quotation ("causing encephalopathy"), because this information is obviously important to the public. I also think that the whole sentence should be moved to the beginning of the section, because of its importance. Baffle (talk) 22:02, 1 May 2018 (UTC)

To add to article

To add to this article: what the "sub-" in "subsalicylate" refers to. 173.88.246.138 (talk) 03:45, 26 September 2021 (UTC)

Wiki Education assignment: PHMD 2040 Service - Learning

This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 January 2022 and 31 May 2022. Further details are available on the course page. Student editor(s): Madiqw (article contribs).

Wiki Education assignment: PHMD 2040 Service - Learning Fall 2023

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— Assignment last updated by Benadryl Submarine (talk) 10:02, 23 November 2023 (UTC)